The winner of this north-west derby will go top of the table for 45 minutes at least.
Everton need just a point to go top. If they finish level, it will be the Toffees' 1,000th draw in top-flight football.
Everton are unbeaten at home in the Premier League; Manchester United yet to win away from home.
This match pits two Premier League ever-presents.
It features the winning most club in this league (Manchester United with 369 victories) and losing most (Everton, beaten 232 times in the Premier League).
United staged a remarkable recovery from 2-0 down after 50 minutes, to win this corresponding fixture 2-4 last April, which took them one step nearer to the title. BBC SPORT
Who do you think will carry the day Everton or Manchester United?